Description
Description
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA region. First identified by Lee and colleagues in 2015, MOTS-C is one of the founding members of a growing class of bioactive peptides translated from short open reading frames in the mitochondrial genome.
Mechanism of Action
Research indicates MOTS-C functions as a regulator of metabolic homeostasis through activation of the AMP-activated protein kinase (AMPK) pathway, modulation of folate–methionine one-carbon metabolism, and translocation to the nucleus where it influences adaptive stress-response gene expression. Its activity is thought to enhance glucose uptake, improve mitochondrial efficiency, and modulate insulin sensitivity in skeletal muscle and adipose tissue.
Research Applications
MOTS-C has been investigated in preclinical studies of metabolic dysregulation, glucose metabolism research, age-related metabolic decline, exercise-mimetic studies, adiposity research, and bone density models. Plasma MOTS-C concentrations have also been studied as a candidate biomarker of mitochondrial function and metabolic aging. It is frequently grouped in research with other mitochondrial-derived peptides such as humanin and the SHLP family.
CAS Number: 1627580-64-6 | Molecular Formula: C???H???N??O?? | Molecular Weight: 2174.49 g/mol | Purity: >99% (HPLC Verified) | For Research Use Only.
📋 View Clinical Trial Reference →
