Description
Description
BPC-157 (Body Protection Compound-157, also referred to as Bepecin or PL-14736) is a synthetic pentadecapeptide consisting of 15 amino acids derived from a partial sequence of human gastric juice protein BPC. As a stable gastric pentadecapeptide, it has been investigated extensively in preclinical models of soft-tissue injury, gastrointestinal mucosal protection, and vascular repair.
Mechanism of Action
Research suggests BPC-157 exerts cytoprotective effects through multiple, partially overlapping pathways: upregulation of vascular endothelial growth factor receptor 2 (VEGFR-2), modulation of nitric oxide (NO) synthesis, promotion of fibroblast migration and tendon outgrowth, and activation of the FAK–paxillin signaling cascade. Unlike many regulatory peptides, BPC-157 demonstrates notable stability in human gastric juice, which has prompted investigation of both parenteral and oral administration routes in animal studies.
Research Applications
Published preclinical literature has examined BPC-157 in the context of tendon-to-bone healing, ligament repair, transected Achilles tendon recovery, gastrointestinal ulcer protection, intestinal inflammation models, neurotrauma research, and angiogenic wound healing. It is frequently studied alongside related cytoprotective peptides such as TB-500 and GHK-Cu in comparative repair-pathway research.
Molecular Formula: C??H??N??O?? | Molecular Weight: 1419.53 g/mol | CAS Number: 137525-51-0 | Purity: >99% (HPLC Verified) | For Research Use Only.
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